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Palladium‐Catalyzed Amidation of Unactivated C(sp 3 )H Bonds: from Anilines to Indolines
Author(s) -
Neumann Julia J.,
Rakshit Souvik,
Dröge Thomas,
Glorius Frank
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903035
Subject(s) - palladium , intramolecular force , indoline , catalysis , chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
Unreactive CH to attractive CN : A palladium‐catalyzed intramolecular direct amidation of unactivated C(sp 3 )H bonds combines CH activation and CN bond formation into one efficient process. Under the optimized conditions, an extraordinary tolerance of functional groups was observed, and numerous indoline derivatives were formed (see scheme).