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The Active Site of an Enzyme Can Host Both Enantiomers of a Racemic Ligand Simultaneously
Author(s) -
Mentel Matthias,
Blankenfeldt Wulf,
Breinbauer Rolf
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902997
Subject(s) - enantiomer , ligand (biochemistry) , chemistry , active site , stereochemistry , enzyme , monomer , biochemistry , organic chemistry , receptor , polymer
Two in one : Proteins usually bind only one enantiomer of a racemic ligand. Now a new binding mode for chiral drugs has been identified by protein crystallography. The homodimeric enzyme PhzA/B (in the picture the monomers are yellow and magenta) can host both enantiomers of a racemic ligand (light and dark gray) in its active site at the same time (dark red Br, blue N, light red O).