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Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage
Author(s) -
Ackermann Lutz,
Vicente Rubén,
Kapdi Anant R.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902996
Subject(s) - transition metal , aryl , catalysis , chemistry , cleavage (geology) , palladium , electrophile , reagent , combinatorial chemistry , bond cleavage , ruthenium , nickel , metal , organic chemistry , materials science , alkyl , fracture (geology) , composite material
The area of transition‐metal‐catalyzed direct arylation through cleavage of CH bonds has undergone rapid development in recent years, and is becoming an increasingly viable alternative to traditional cross‐coupling reactions with organometallic reagents. In particular, palladium and ruthenium catalysts have been described that enable the direct arylation of (hetero)arenes with challenging coupling partners—including electrophilic aryl chlorides and tosylates as well as simple arenes in cross‐dehydrogenative arylations. Furthermore, less expensive copper, iron, and nickel complexes were recently shown to be effective for economically attractive direct arylations.