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Methionine Can Favor DNA Platination by trans ‐Coordinated Platinum Antitumor Drugs
Author(s) -
Li Chan,
Li Zhanyong,
Sletten Einar,
Arnesano Fabio,
Losacco Maurizio,
Natile Giovanni,
Liu Yangzhong
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902948
Subject(s) - cisplatin , chemistry , carboplatin , dna , stereochemistry , platinum , adduct , dna repair , oxaliplatin , methionine , biochemistry , chemotherapy , cancer , biology , amino acid , catalysis , genetics , colorectal cancer , organic chemistry
It happens at the Met : The DNA platination rate is substantially enhanced by methionine binding to trans ‐coordinated platinum antitumor drugs (see scheme). Platinum–methionine intermediates were also formed in a cell system and could play a major role in the mechanism of action of trans compounds.