Polarity‐Directed One‐Pot Asymmetric Cascade Reactions Mediated by Two Catalysts in an Aqueous Buffer | Zendy

Scroggins Steven T. | Zendy; Chi Yonggui | Zendy; Fréchet Jean M. J. | Zendy

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Polarity‐Directed One‐Pot Asymmetric Cascade Reactions Mediated by Two Catalysts in an Aqueous Buffer

Author(s) -

Scroggins Steven T.,

Chi Yonggui,

Fréchet Jean M. J.

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200902945

Subject(s) - nitromethane , aldehyde , catalysis , polarity (international relations) , cascade , chemistry , aqueous solution , buffer (optical fiber) , cascade reaction , aqueous medium , combinatorial chemistry , organic chemistry , chromatography , biochemistry , telecommunications , computer science , cell

A crossing between phases : Polarity makes a difference in distinguishing substrates of otherwise nearly identical chemical reactivities. A one‐pot cascade reaction involving nitromethane and two aliphatic aldehydes with similar reactivities has been developed (see scheme). The use of a biphasic reaction medium with two different organic catalysts results in the controlled incorporation of both aldehyde substrates into a single major cross‐product.

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