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Highly Efficient and Chemoselective Peptide Ubiquitylation
Author(s) -
Ajish Kumar K. S.,
HajYahya Mahmood,
Olschewski Diana,
Lashuel Hilal A.,
Brik Ashraf
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902936
Subject(s) - kiss (tnc) , ubiquitin , residue (chemistry) , peptide , lysine , computer science , chemistry , biochemistry , computational biology , biology , computer network , amino acid , gene
Loving kiss of death : A highly efficient and chemoselective method for ubiquitylation of peptides using δ‐mercaptolysine to assist isopeptide formation between the ε‐NH 2 of the lysine residue and the activated C‐terminal glycine of ubiquitin (Ub) is presented.