Premium
Efficient Enantioselective Synthesis of Optically Active Diols by Asymmetric Hydrogenation with Modular Chiral Metal Catalysts
Author(s) -
Kadyrov Renat,
Koenigs René M.,
Brinkmann Claus,
Voigtlaender David,
Rueping Magnus
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902835
Subject(s) - enantioselective synthesis , vicinal , modular design , ruthenium , asymmetric hydrogenation , catalysis , chemistry , combinatorial chemistry , aryl , optically active , computer science , alkyl , organic chemistry , stereochemistry , operating system
Valuable vicinal 1,2‐diols can be prepared with high enantioselectivity by the asymmetric ruthenium‐catalyzed hydrogenation of aryl‐ and alkyl‐substituted α‐hydroxy ketones (see scheme). The ligands, which are distinguished by their modular construction, display excellent enantioface differentiation.