Premium
Self‐Replicating Amphiphilic β‐Sheet Peptides
Author(s) -
Rubinov Boris,
Wagner Nathaniel,
Rapaport Hanna,
Ashkenasy Gonen
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902790
Subject(s) - amphiphile , chemistry , combinatorial chemistry , nucleophile , peptide , replication (statistics) , electrophile , nanotechnology , computer science , biochemistry , computational biology , organic chemistry , materials science , biology , copolymer , virology , polymer , catalysis
Simple peptides can do that too: Synthetic amphiphilic peptides 1 , formed of electrophilic (E) and nucleophilic (N) precursors, are close analogues of the Glu‐(Phe‐Glu) n molecules. The peptides form soluble one‐dimensional β‐sheet aggregates in water (see picture), and serve to significantly accelerate chemical ligation and self‐replication.