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Multiplexed Protein Arrays Enabled by Polymer Pen Lithography: Addressing the Inking Challenge
Author(s) -
Zheng Zijian,
Daniel Weston L.,
Giam Louise R.,
Huo Fengwei,
Senesi Andrew J.,
Zheng Gengfeng,
Mirkin Chad A.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902649
Subject(s) - microscale chemistry , lithography , multiplexing , nanotechnology , materials science , polymer , soft lithography , computer science , optoelectronics , fabrication , composite material , telecommunications , mathematics education , mathematics , medicine , alternative medicine , pathology
High‐end printer : A novel way of using a polymer pen lithography (PPL) array mould to localize different inks on the pens of a PPL array has been developed. This technique allows for rapid pen inking and subsequent generation of multiplexed patterns of up to 150 000 nano‐ and microscale protein features per second (see picture). It is a general approach, which in principle can be extended to any substance that can be transported by PPL.