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Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for In Vivo Cancer Therapy
Author(s) -
Liu Zhuang,
Fan Alice C.,
Rakhra Kavya,
Sherlock Sarah,
Goodwin Andrew,
Chen Xiaoyuan,
Yang Qiwei,
Felsher Dean W.,
Dai Hongjie
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902612
Subject(s) - stacking , doxorubicin , carbon nanotube , supramolecular chemistry , in vivo , materials science , nanotechnology , drug , drug delivery , chemistry , pharmacology , chemotherapy , medicine , organic chemistry , biology , crystal structure , microbiology and biotechnology
The evidence is stacking up : Many therapeutic advantages such as prolonged circulation in the blood, increased tumor drug uptake, enhanced therapeutic efficacy, and markedly reduced toxic side effects are provided by a carbon nanotube based chemotherapeutic formulation (see picture). In this system, doxorubicin (DOX) is loaded onto the sidewalls of functionalized single‐walled carbon nanotubes by supramolecular π–π stacking.