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Direct, Electronic MicroRNA Detection for the Rapid Determination of Differential Expression Profiles
Author(s) -
Yang Hong,
Hui Angela,
Pampalakis George,
Soleymani Leyla,
Liu FeiFei,
Sargent Edward H.,
Kelley Shana O.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902577
Subject(s) - microrna , rna , chip , biosensor , multiplexing , chemistry , microelectrode , computational biology , microbiology and biotechnology , nanotechnology , gene , biology , materials science , biochemistry , computer science , electrode , telecommunications
In the time it takes for lunch : An electronic chip featuring nanostructured microelectrodes (NMEs) enables the analysis of microRNA expression profiles in just 30 min in small RNA samples without enzymatic amplification or sequence labeling. The multiplexed chip detects the hybridization of microRNA targets to NME surfaces and provides large electrocatalytic gain through the use of an ultrasensitive redox reporter system (see picture).