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pH‐Regulated Asymmetric Transfer Hydrogenation of Quinolines in Water
Author(s) -
Wang Chao,
Li Chaoqun,
Wu Xiaofeng,
Pettman Alan,
Xiao Jianliang
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902570
Subject(s) - transfer hydrogenation , sodium formate , quinoline , aryl , rhodium , chemistry , catalysis , alkyl , combinatorial chemistry , formate , organic chemistry , medicinal chemistry , ruthenium
In buffered water , a broad range of quinoline derivatives underwent asymmetric transfer hydrogenation in air with the rhodium catalyst 1 and sodium formate as the hydrogen source to furnish synthetically important 1,2,3,4‐tetrahydroquinolines with excellent enantioselectivities (see scheme; R=H, Me, F, Cl, Br, OMe; R′=alkyl, aryl).
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