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A Synthetic Vaccine Consisting of a Tumor‐Associated Sialyl‐T N ‐MUC1 Tandem‐Repeat Glycopeptide and Tetanus Toxoid: Induction of a Strong and Highly Selective Immune Response
Author(s) -
Kaiser Anton,
Gaidzik Nikola,
Westerlind Ulrika,
Kowalczyk Danuta,
Hobel Alexandra,
Schmitt Edgar,
Kunz Horst
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902564
Subject(s) - glycopeptide , toxoid , tetanus , immune system , muc1 , antigen , chemistry , vaccination , immunology , virology , biology , microbiology and biotechnology , antibiotics
An ideal combination : The vaccine A is obtained by conjugation of the synthetic tumor‐associated sialyl‐T N ‐MUC1 glycopeptide antigen to tetanus toxoid (molecular weight >150 000). Vaccine A induces a very strong and selective immune response against the glycopeptide structure in wild‐type mice (Balb/c).