A Synthetic Vaccine Consisting of a Tumor‐Associated Sialyl‐T N ‐MUC1 Tandem‐Repeat Glycopeptide and Tetanus Toxoid: Induction of a Strong and Highly Selective Immune Response | Zendy

Kaiser Anton | Zendy; Gaidzik Nikola | Zendy; Westerlind Ulrika | Zendy; Kowalczyk Danuta | Zendy; Hobel Alexandra | Zendy; Schmitt Edgar | Zendy; Kunz Horst | Zendy

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A Synthetic Vaccine Consisting of a Tumor‐Associated Sialyl‐T N ‐MUC1 Tandem‐Repeat Glycopeptide and Tetanus Toxoid: Induction of a Strong and Highly Selective Immune Response

Author(s) -

Kaiser Anton,

Gaidzik Nikola,

Westerlind Ulrika,

Kowalczyk Danuta,

Hobel Alexandra,

Schmitt Edgar,

Kunz Horst

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200902564

Subject(s) - glycopeptide , toxoid , tetanus , immune system , muc1 , antigen , chemistry , vaccination , immunology , virology , biology , microbiology and biotechnology , antibiotics

An ideal combination : The vaccine A is obtained by conjugation of the synthetic tumor‐associated sialyl‐T N ‐MUC1 glycopeptide antigen to tetanus toxoid (molecular weight >150 000). Vaccine A induces a very strong and selective immune response against the glycopeptide structure in wild‐type mice (Balb/c).

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