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In Vivo, In Situ Tissue Analysis Using Rapid Evaporative Ionization Mass Spectrometry
Author(s) -
Schäfer KarlChristian,
Dénes Júlia,
Albrecht Katalin,
Szaniszló Tamás,
Balog Júlia,
Skoumal Réka,
Katona Mária,
Tóth Miklós,
Balogh Lajos,
Takáts Zoltán
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902546
Subject(s) - mass spectrometry , in situ , biological tissue , evaporation , in vivo , mass spectrometry imaging , chemistry , analytical chemistry (journal) , materials science , pathology , chromatography , biomedical engineering , medicine , biology , physics , microbiology and biotechnology , organic chemistry , thermodynamics
Beam me up : A novel mass spectrometric ionization technique based on rapid evaporation of biological tissues (see picture) can be used to analyze vital tissues during surgical intervention as well as for processed tissue specimens. A tissue identification system based on principal‐component analysis was developed. The method differentiates malignant tumor cells from the surrounding healthy tissue.