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Recycling the Waste: The Development of a Catalytic Wittig Reaction
Author(s) -
O'Brien Christopher J.,
Tellez Jennifer L.,
Nixon Zachary S.,
Kang Lauren J.,
Carter Andra L.,
Kunkel Stephen R.,
Przeworski Katherine C.,
Chass Gregory A.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902525
Subject(s) - wittig reaction , phosphine oxide , yield (engineering) , catalysis , phosphine , scale (ratio) , chemistry , organic chemistry , combinatorial chemistry , computer science , materials science , physics , quantum mechanics , metallurgy
It's all in the ring : 3‐Methyl‐1‐phenylphospholane‐1‐oxide (4–10 mol %) and an organosilane reducing agent are the key components in the first Wittig reaction catalytic in phosphine. The protocol also functions well on larger scale: a reaction on a 30 mmol scale yielded 3.39 g of product, corresponding to a yield of 67 %.
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