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What is Cooperativity?
Author(s) -
Hunter Christopher A.,
Anderson Harry L.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902490
Subject(s) - cooperativity , allosteric regulation , supramolecular chemistry , chemistry , computational biology , cooperative binding , ligand (biochemistry) , allosteric enzyme , computer science , biophysics , biochemistry , binding site , crystallography , biology , receptor , crystal structure
The lamprey holds the clue to the link between supramolecular self‐assembly and allosteric ligand binding. Chelate cooperativity in self‐assembled structures results in denaturation behavior that is indistinguishable from allosteric ligand binding. The chelate effect is the most common origin of positive cooperativity, yet its significance has been widely overlooked.