Catalytic Enantioselective Trifluoromethylation of Azomethine Imines with Trimethyl(trifluoromethyl)silane | Zendy

Kawai Hiroyuki | Zendy; Kusuda Akihiro | Zendy; Nakamura Shuichi | Zendy; Shiro Motoo | Zendy; Shibata Norio | Zendy

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Catalytic Enantioselective Trifluoromethylation of Azomethine Imines with Trimethyl(trifluoromethyl)silane

Author(s) -

Kawai Hiroyuki,

Kusuda Akihiro,

Nakamura Shuichi,

Shiro Motoo,

Shibata Norio

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200902457

Subject(s) - trifluoromethylation , enantioselective synthesis , chemistry , trifluoromethyl , silane , salt (chemistry) , catalysis , bromide , cinchona , organic chemistry , combinatorial chemistry , alkyl

It′s a cinch! The title reaction with azomethine imines 1 uses an operationally simple procedure, based on the combination of the bromide salt of cinchona alkaloids ( 3 ) and KOH. The procedure is reliable and general. Trifluoromethyl‐substituted amines can be accessed by a two‐step deprotection of the product ( S )‐ 2 .

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