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Design of a G‐Quadruplex Topology through Glycosidic Bond Angles
Author(s) -
Webba da Silva Mateus,
Trajkovski Marko,
Sannohe Yuta,
Ma'ani Hessari Nason,
Sugiyama Hiroshi,
Plavec Janez
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902454
Subject(s) - glycosidic bond , formalism (music) , g quadruplex , network topology , topology (electrical circuits) , inference , computer science , theoretical computer science , mathematics , chemistry , dna , artificial intelligence , combinatorics , biochemistry , visual arts , enzyme , operating system , art , musical
Building regulations : Thus far the discovery of novel DNA quadruplex topologies was either serendipitous or through coincidental emergence. Now a deductive system, based on the glycosidic bond angle of guanosines, can be used to derive a set of inference rules for the prediction of both known and theoretical quadruplex topologies. This formalism was used to design and control the self‐assembly of a novel DNA quadruplex architecture.
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