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Copper‐Catalyzed CC Bond Formation through CH Functionalization: Synthesis of Multisubstituted Indoles from N ‐Aryl Enaminones
Author(s) -
Bernini Roberta,
Fabrizi Giancarlo,
Sferrazza Alessio,
Cacchi Sandro
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902440
Subject(s) - intramolecular force , indole test , aryl , catalysis , yield (engineering) , chemistry , medicinal chemistry , copper , surface modification , halogen , combinatorial chemistry , stereochemistry , organic chemistry , materials science , alkyl , metallurgy
A variety of functionalities , including the whole range of halogen substituents, are tolerated in the title reaction, an intramolecular approach for the construction of a multisubstituted indole skeleton from readily available enaminones (see scheme; phen=1,10‐phenanthroline). The indole products are also prepared directly in high yield from α,β‐ynones and primary amines.