Premium
Genome‐Free Viral Capsids as Multivalent Carriers for Taxol Delivery
Author(s) -
Wu Wesley,
Hsiao Sonny C.,
Carrico Zachary M.,
Francis Matthew B.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902426
Subject(s) - capsid , bioconjugation , oncolytic virus , chemistry , virology , genome , computational biology , computer science , virus , combinatorial chemistry , biology , biochemistry , gene
Delivery by Trojan horse : A water‐soluble derivative of the chemotherapeutic agent taxol was synthesized with bioconjugation functionality and attached to capsids of the bacteriophage MS2 (see picture). The modified capsids retained their form and released taxol when incubated with MCF‐7 cells. The resulting cell‐viability levels were similar to those observed upon treatment with free taxol in solution.