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Total Synthesis of Celogentin C
Author(s) -
Ma Bing,
Litvinov Dmitry N.,
He Liwen,
Banerjee Biplab,
Castle Steven L.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902425
Subject(s) - knoevenagel condensation , total synthesis , chemistry , conjugate , stereochemistry , combinatorial chemistry , computer science , organic chemistry , mathematics , mathematical analysis , catalysis
Crazy cross‐links : The first total synthesis of a member of the celogentin/moroidin family of antimitotic bicyclic peptides features a Knoevenagel condensation–radical conjugate addition sequence to install the LeuTrp cross‐link and an indole–imidazole oxidative coupling to fashion the TrpHis cross‐link (see structure).