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A Metal–Collagen Peptide Framework for Three‐Dimensional Cell Culture
Author(s) -
Pires Marcos M.,
Przybyla David E.,
Chmielewski Jean
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902375
Subject(s) - peptide , regenerative medicine , chelation , computer science , computational biology , chemistry , combinatorial chemistry , biochemistry , cell , nanotechnology , information retrieval , biology , materials science , organic chemistry
It won′t overstay its welcome : Metal ions trigger the rapid assembly of a triple‐helical collagen‐based peptide with ligands at the ends and center into a fibrous three‐dimensional mesh under physiological conditions (see picture). Importantly for applications in regenerative medicine, a mild chelating agent causes rapid disassembly of the mesh. Human endothelial cells were readily encapsulated and cultured within the collagen‐peptide network.