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Kinetic Resolution of Quaternary and Tertiary β‐Hydroxy Esters
Author(s) -
Schipper Derek J.,
Rousseaux Sophie,
Fagnou Keith
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902373
Subject(s) - kinetic resolution , ketone , aldol reaction , aldehyde , tertiary alcohols , enantiomer , chemistry , resolution (logic) , selectivity , tertiary amine , organic chemistry , enantioselective synthesis , alcohol , catalysis , computer science , artificial intelligence
Selectivity factors : The resolution of tertiary and secondary alcohols, which arise from ketone and aldehyde aldol additions, proceeds in the presence of (1 S ,2 R )‐ N ‐methylephedrine (see example). The method is technically simple, easily scalable, and provides tertiary and secondary alcohols in high enantiomeric ratios.