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Cardiosulfa, a Small Molecule that Induces Abnormal Heart Development in Zebrafish, and Its Biological Implications
Author(s) -
Ko SungKyun,
Jin Hui Juan,
Jung DaWoon,
Tian Xizhe,
Shin Injae
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902370
Subject(s) - zebrafish , heart development , embryo , biology , human heart , microbiology and biotechnology , anatomy , medicine , genetics , gene , embryonic stem cell
A change of heart : Cardiosulfa, a small molecule that induces heart deformation during zebrafish development, has been identified by using a forward chemical‐genetic approach. Zebrafish embryos exposed to cardiosulfa have a narrow and elongated heart within an enlarged pericardial sac (see picture; heart marked with green fluorescent protein).
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