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Building Addressable Libraries: Site‐Selective Lewis Acid (Scandium(III)) Catalyzed Reactions
Author(s) -
Bi Bo,
Maurer Karl,
Moeller Kevin D.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902350
Subject(s) - lewis acids and bases , reagent , scandium , catalysis , chemistry , combinatorial chemistry , electrode , lewis acid catalysis , tetrahydropyran , organic chemistry , inorganic chemistry , ring (chemistry)
Reagent confinement : Lewis acid catalyzed reactions have been conducted on arrays with either 1024 or 12 544 microelectrodes cm −2 . A Sc III species generated at the electrodes is employed as the Lewis acid, and the reagent is confined to the electrodes through the use of a solution‐phase reductant. A multicomponent synthesis of a tetrahydropyran (see scheme), a Diels–Alder reaction, and an esterification reaction are all compatible with this strategy.