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A Symmetry‐Based Concise Formal Synthesis of Platencin, a Novel Lead against “Superbugs”
Author(s) -
Ghosh Arun K.,
Xi Kai
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902338
Subject(s) - formal synthesis , combinatorial chemistry , chemistry , key (lock) , core (optical fiber) , protecting group , stereochemistry , computer science , organic chemistry , telecommunications , alkyl , computer security
Quick access : A concise and efficient formal synthesis of platencin has been accomplished in nine steps from a commercially available starting material. The synthesis utilized only one protecting group. The base‐catalyzed Michael cyclization of precursor 1 afforded the key diketone 2 , which was converted into the desired core structure 4 via the radical intermediate 3 .
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