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Heck Reactions with Palladium Nanoparticles in Ionic Liquids: Coupling of Aryl Chlorides with Deactivated Olefins
Author(s) -
Calò Vincenzo,
Nacci Angelo,
Monopoli Antonio,
Cotugno Pietro
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902337
Subject(s) - aryl , palladium , ionic liquid , heck reaction , catalysis , chemistry , ionic bonding , ligand (biochemistry) , combinatorial chemistry , coupling (piping) , organic chemistry , ion , materials science , biochemistry , alkyl , receptor , metallurgy
Smooth operators : Heck reactions of aryl chlorides were catalyzed by ligand‐free palladium acetate in a molten mixture of tetraalkylammonium ionic liquids under aerobic and relatively mild conditions (see example). Deactivated electron‐rich aryl chlorides reacted with a wide array of substituted alkenes under these conditions, which thus enabled the coupling of combinations of substrates that are commonly unreactive with traditional catalysts.