A General and Mild Palladium‐Catalyzed Domino Reaction for the Synthesis of 2 H‐ Indazoles | Zendy

Halland Nis | Zendy; Nazaré Marc | Zendy; R'kyek Omar | Zendy; Alonso Jorge | Zendy; Urmann Matthias | Zendy; Lindenschmidt Andreas | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A General and Mild Palladium‐Catalyzed Domino Reaction for the Synthesis of 2 H‐ Indazoles

Author(s) -

Halland Nis,

Nazaré Marc,

R'kyek Omar,

Alonso Jorge,

Urmann Matthias,

Lindenschmidt Andreas

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200902323

Subject(s) - regioselectivity , palladium , hydroamination , catalysis , domino , intramolecular force , isomerization , chemistry , acetylene , cascade reaction , hydrazine (antidepressant) , amination , dimethylformamide , combinatorial chemistry , sonogashira coupling , medicinal chemistry , organic chemistry , solvent , chromatography

Practical and highly versatile , the reaction of readily available (2‐chlorophenyl)acetylene and hydrazine substrates affords substituted 2 H ‐indazoles in just a few hours under very mild reaction conditions (see scheme; DMF= N , N ‐dimethylformamide). The catalyzed domino sequence consists of a regioselective coupling followed by an intramolecular hydroamination and subsequent isomerization of the resulting exocyclic bond.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research