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Dendritic DNA Building Blocks for Amplified Detection Assays and Biomaterials
Author(s) -
Feldkamp Udo,
Saccà Barbara,
Niemeyer Christof M.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902285
Subject(s) - dna , ribosome , template , biosensor , rna , in vitro , nanotechnology , chemistry , microbiology and biotechnology , computational biology , biology , gene , materials science , biochemistry
DNA branches out : Recent advances in the assembly of dendritic DNA structures enable applications in biosensing of pathogens and the generation of novel pads of DNA hydrogel biomaterials (see scheme, left). These pads are immersed in a cell extract containing RNA polymerase (red), ribosomes (yellow), and other components for in vitro protein biosynthesis, where they can be used as templates for cell‐free protein production.