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Copper‐Catalyzed Cross‐Couplings with Part‐per‐Million Catalyst Loadings
Author(s) -
Larsson PerFredrik,
Correa Arkaitz,
Carril Monica,
Norrby PerOla,
Bolm Carsten
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902236
Subject(s) - catalysis , nucleophile , copper , ligand (biochemistry) , iodide , salt (chemistry) , chemistry , inorganic chemistry , organic chemistry , biochemistry , receptor
Homeopathic doses : The presence of 0.001 mol % of a copper salt can be sufficient to catalyze arylation reactions of various nucleophiles with phenyl iodide. The two most important factors governing the reaction outcome are the ligand quantity and the temperature.