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Organic–Inorganic Nanospheres with Responsive Molecular Gates for Drug Storage and Release
Author(s) -
Corma Avelino,
Díaz Urbano,
Arrica María,
Fernández Eduardo,
Ortega Ílida
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902208
Subject(s) - nanotechnology , drug delivery , organic molecules , chemistry , molecule , chemical engineering , combinatorial chemistry , materials science , organic chemistry , engineering
Catch and release : Bridged silsesquioxanes act as organic–inorganic precursors for nanospheres to encapsulate bioactive molecules for drug‐delivery applications. The nanosystems (see picture) are constructed from an liposomal core containing bioactive molecules and an network shell formed by silica and organic ester fragments that can act as responsive molecular gates.