Premium
Switching the Chirality of the Metal Environment Alters the Coordination Mode in Designed Peptides
Author(s) -
Peacock Anna F. A.,
Stuckey Jeanne A.,
Pecoraro Vincent L.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902166
Subject(s) - chirality (physics) , coiled coil , chemistry , stereochemistry , crystallography , nanotechnology , materials science , physics , biochemistry , chiral perturbation theory , pion , particle physics , nambu–jona lasinio model
Outsiders make their presence felt : When the chirality of a single layer of amino acids was switched in a three‐stranded coiled coil (see picture), X‐ray crystallography revealed minimal perturbation of the α‐helical backbone of the designed structure. In contrast, spectroscopic studies of cadmium binding showed that this switch in chirality dramatically altered the coordination environment and the position of binding.