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Palladium‐Catalyzed Hydroxylation of Aryl Halides under Ambient Conditions
Author(s) -
Sergeev Alexey G.,
Schulz Thomas,
Torborg Christian,
Spannenberg Anke,
Neumann Helfried,
Beller Matthias
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902148
Subject(s) - aryl , phosphine , hydroxylation , halide , catalysis , palladium , chemistry , ligand (biochemistry) , organic chemistry , phenols , stoichiometry , combinatorial chemistry , medicinal chemistry , biochemistry , alkyl , receptor , enzyme
Turning down the heat : The first room temperature Pd‐catalyzed synthesis of phenols from aryl bromides and chlorides is presented. Stoichiometric studies of Pd‐mediated hydroxylation of aryl halides employing a bulky imidazolyl‐phosphine ligand and the novel palladium precursor [Pd(cod)(CH 2 SiMe 3 ) 2 ] led to development of efficient catalytic synthesis of phenols under ambient conditions (see scheme; Ad=adamantyl, cod=1,5‐cyclooctadiene).