Palladium‐Catalyzed Hydroxylation of Aryl Halides under Ambient Conditions | Zendy

Sergeev Alexey G. | Zendy; Schulz Thomas | Zendy; Torborg Christian | Zendy; Spannenberg Anke | Zendy; Neumann Helfried | Zendy; Beller Matthias | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Palladium‐Catalyzed Hydroxylation of Aryl Halides under Ambient Conditions

Author(s) -

Sergeev Alexey G.,

Schulz Thomas,

Torborg Christian,

Spannenberg Anke,

Neumann Helfried,

Beller Matthias

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200902148

Subject(s) - aryl , phosphine , hydroxylation , halide , catalysis , palladium , chemistry , ligand (biochemistry) , organic chemistry , phenols , stoichiometry , combinatorial chemistry , medicinal chemistry , biochemistry , alkyl , receptor , enzyme

Turning down the heat : The first room temperature Pd‐catalyzed synthesis of phenols from aryl bromides and chlorides is presented. Stoichiometric studies of Pd‐mediated hydroxylation of aryl halides employing a bulky imidazolyl‐phosphine ligand and the novel palladium precursor [Pd(cod)(CH 2 SiMe 3 ) 2 ] led to development of efficient catalytic synthesis of phenols under ambient conditions (see scheme; Ad=adamantyl, cod=1,5‐cyclooctadiene).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research