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Transition‐Metal‐Mediated Reactions for C sp 2 F Bond Construction: The State of Play
Author(s) -
Brown John M.,
Gouverneur Véronique
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902121
Subject(s) - reductive elimination , electrophile , reagent , nucleophile , chemistry , ligand (biochemistry) , transition metal , combinatorial chemistry , computational chemistry , metal , medicinal chemistry , stereochemistry , catalysis , organic chemistry , receptor , biochemistry
It′s a rate thing : Crucial conceptual advances have allowed for the development of a Pd‐mediated pathway to C aryl F by using either electrophilic (right) or nucleophilic (left) fluorinating reagents. Of significance is the recognition that Pd IV intermediates reduce the barrier to CF reductive elimination and the use of an ancillary bulky ligand to force reductive elimination from a 14‐electron Pd II complex.