Chemoselective Asymmetric N‐Allylic Alkylation of Indoles with Morita–Baylis–Hillman Carbonates | Zendy

Cui HaiLei | Zendy; Feng Xin | Zendy; Peng Jing | Zendy; Lei Jie | Zendy; Jiang Kun | Zendy; Chen YingChun | Zendy

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Chemoselective Asymmetric N‐Allylic Alkylation of Indoles with Morita–Baylis–Hillman Carbonates

Author(s) -

Cui HaiLei,

Feng Xin,

Peng Jing,

Lei Jie,

Jiang Kun,

Chen YingChun

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200902093

Subject(s) - tsuji–trost reaction , quinoline , indole test , cinchona , combinatorial chemistry , chemistry , computer science , catalysis , organic chemistry , enantioselective synthesis

Give me convenience : The title transformation has been developed by employing metal‐free catalysis of modified cinchona alkaloids. Moderate to excellent enantioselectivities have been achieved for a broad array of substrates (see scheme). This reaction also provides a convenient method to prepare multiply functionalized pyrrolo[1,2‐ a ]indole and pyrrolo[3,2,1‐ ij ]quinoline derivatives.

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