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Chemoselective Asymmetric N‐Allylic Alkylation of Indoles with Morita–Baylis–Hillman Carbonates
Author(s) -
Cui HaiLei,
Feng Xin,
Peng Jing,
Lei Jie,
Jiang Kun,
Chen YingChun
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902093
Subject(s) - tsuji–trost reaction , quinoline , indole test , cinchona , combinatorial chemistry , chemistry , computer science , catalysis , organic chemistry , enantioselective synthesis
Give me convenience : The title transformation has been developed by employing metal‐free catalysis of modified cinchona alkaloids. Moderate to excellent enantioselectivities have been achieved for a broad array of substrates (see scheme). This reaction also provides a convenient method to prepare multiply functionalized pyrrolo[1,2‐ a ]indole and pyrrolo[3,2,1‐ ij ]quinoline derivatives.