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Asymmetric Self‐ and Cross‐Aldol Reactions of Glycolaldehyde Catalyzed by D ‐Fructose‐6‐phosphate Aldolase
Author(s) -
Garrabou Xavier,
Castillo José A.,
GuérardHélaine Christine,
Parella Teodor,
Joglar Jesús,
Lemaire Marielle,
Clapés Pere
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902065
Subject(s) - aldol reaction , glycolaldehyde , aldolase a , chemistry , glyceraldehyde , aldehyde , aldolase b , fructose , fructose bisphosphate aldolase , enzyme , catalysis , organic chemistry , stereochemistry , dehydrogenase
New facets of enzyme activity : D ‐Fructose‐6‐phosphate aldolase (FSA) catalyzes the self‐aldol reaction of glycolaldehyde (GA) and its cross‐aldol addition to other aldehydes. As the affinity of GA for FSA as a donor is higher than that as an acceptor, cross‐aldol reactions are possible with good to poor aldehyde acceptors if the concentration of GA in the reaction is kept low.