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Highly Regio‐ and Enantioselective Copper‐Catalyzed Hydroboration of Styrenes
Author(s) -
Noh Dongwan,
Chea Heesung,
Ju Junghwan,
Yun Jaesook
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902015
Subject(s) - hydroboration , enantioselective synthesis , regioselectivity , chemistry , reagent , catalysis , organic chemistry , copper , combinatorial chemistry
An existing challenge is the development of efficient regioselective catalytic systems that are compatible with stable hydroboration reagents and can be rendered enantioselective by the use of nonracemic ligands. Copper(I) complexes with chelating phosphines catalyzed the regio‐ and enantioselective hydroboration of styrenes with pinacolborane (PinBH) at room temperature to afford the corresponding branched boronate esters (see example).