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Nickel‐Catalyzed Three‐Component [2+2+2] Cycloaddition Reaction of Arynes, Alkenes, and Alkynes
Author(s) -
Qiu Zaozao,
Xie Zuowei
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902006
Subject(s) - cycloaddition , aryne , nickel , trimethylsilyl , catalysis , component (thermodynamics) , regioselectivity , chemistry , combinatorial chemistry , computer science , organic chemistry , physics , thermodynamics
Three in one : Nickel‐catalyzed three‐component cycloaddition reactions of readily available arynes, activated alkenes, and alkynes gave a series of substituted 1,2‐dihydronaphthalenes in moderate to very good yields with excellent chemo‐ and regioselectivity (see scheme, TMS=trimethylsilyl, cod=1,5‐cyclooctadiene).