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Exciton‐Controlled Hybridization‐Sensitive Fluorescent Probes: Multicolor Detection of Nucleic Acids
Author(s) -
Ikeda Shuji,
Kubota Takeshi,
Yuki Mizue,
Okamoto Akimitsu
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200902000
Subject(s) - fluorescence , nucleic acid , quenching (fluorescence) , interference (communication) , exciton , chemistry , nanotechnology , biophysics , computer science , biology , biochemistry , physics , materials science , optics , telecommunications , channel (broadcasting) , quantum mechanics
A colorful bunch : A series of fluorescent probes designed on the basis of fluorescence quenching caused by an excitonic interaction contain different dye moieties and fluoresce in various colors upon hybridization with their target nucleic acid. The picture shows simultaneous fluorescence in three colors in the nucleus of a cell containing an excess of three different microRNA strands. Left: differential interference contrast image.