Expedient Synthesis of N‐Fused Indoles: A CF Activation and CH Insertion Approach | Zendy

Fuchibe Kohei | Zendy; Kaneko Tsukasa | Zendy; Mori Keiji | Zendy; Akiyama Takahiko | Zendy

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Expedient Synthesis of N‐Fused Indoles: A CF Activation and CH Insertion Approach

Author(s) -

Fuchibe Kohei,

Kaneko Tsukasa,

Mori Keiji,

Akiyama Takahiko

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200901986

Subject(s) - amination , indole test , combinatorial chemistry , chemistry , core (optical fiber) , common core , stereochemistry , palladium , catalysis , computer science , organic chemistry , telecommunications

Easy does it : A wide range of N‐fused indole skeletons, which are core structures of many biologically potent molecules, are successfully furnished by a niobium‐catalyzed C(sp 3 )H insertion reaction (see picture). The precursors are readily prepared by a palladium‐catalyzed amination reaction of bromotrifluorotoluenes with cyclic amines.

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