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Light‐Directed Protein Binding of a Biologically Relevant β‐Sheet
Author(s) -
Hoppmann Christian,
Seedorff Sabine,
Richter Anja,
Fabian Heinz,
Schmieder Peter,
RückBraun Karola,
Beyermann Michael
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901933
Subject(s) - photoswitch , azobenzene , chemistry , monomer , isomerization , biochemistry , stereochemistry , computational biology , biophysics , combinatorial chemistry , biology , photochemistry , organic chemistry , molecule , catalysis , polymer
Lit‐up β attracts α : An azobenzene‐ω‐amino acid is incorporated as a photoswitch into a β‐hairpin motif that mimics the binding site in neuronal NO synthase for α‐syntrophin. Light‐induced isomerization reversibly converts the stable monomer model peptide from its nonbinding, nonstructured trans form into the β‐sheet‐forming cis form which shows a remarkable affinity for α‐syntrophin.