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Iridium‐Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols
Author(s) -
Mantilli Luca,
Gérard David,
Torche Sonya,
Besnard Céline,
Mazet Clément
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901863
Subject(s) - isomerization , iridium , allylic rearrangement , catalysis , primary (astronomy) , chemistry , hydride , alcohol , organic chemistry , photochemistry , medicinal chemistry , hydrogen , physics , astronomy
Nothing to sm(Ir)k at : Under appropriate reaction conditions, iridium hydride catalysts promote the isomerization of primary allylic alcohols. The best catalysts, like ( R )‐ 1 (P green, O red, N blue, Ir yellow), deliver the desired chiral aldehydes with excellent enantioselectivity and good yields. Mechanistic hypotheses have been developed on the basis of preliminary investigations.