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Enantioselective Linchpin Catalysis by SOMO Catalysis: An Approach to the Asymmetric α‐Chlorination of Aldehydes and Terminal Epoxide Formation
Author(s) -
Amatore Muriel,
Beeson Teresa D.,
Brown Sean P.,
MacMillan David W. C.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901855
Subject(s) - enantioselective synthesis , epoxide , catalysis , terminal (telecommunication) , chemistry , transformation (genetics) , combinatorial chemistry , stereochemistry , organic chemistry , computer science , biochemistry , telecommunications , gene
Time for SOme MOre : For the first time SOMO (singly occupied molecular orbital) activation has been exploited to allow a new approach to the α‐chlorination of aldehydes. This transformation can be readily implemented as part of a linchpin catalysis approach to the enantioselective production of terminal epoxides.