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A Powerful Chiral Counteranion Motif for Asymmetric Catalysis
Author(s) -
GarcíaGarcía Pilar,
Lay Frank,
GarcíaGarcía Patricia,
Rabalakos Constantinos,
List Benjamin
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901768
Subject(s) - enantioselective synthesis , catalysis , chemistry , aldol reaction , imide , organocatalysis , combinatorial chemistry , stereochemistry , organic chemistry
Room to swing a cat : A chiral disulfonimide has been designed as a powerful new motif for asymmetric catalysis. As a first illustration, a highly efficient and enantioselective Mukaiyama aldol reaction has been developed (see scheme). The actual catalyst is proposed to be an N ‐silyl imide which is generated in situ.
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