Premium
Radicals and Transition‐Metal Catalysis: An Alliance Par Excellence to Increase Reactivity and Selectivity in Organic Chemistry
Author(s) -
Ford Leigh,
Jahn Ullrich
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901761
Subject(s) - catalysis , reactivity (psychology) , chemistry , radical , catalytic cycle , rhodium , transition metal , selectivity , cobalt , regioselectivity , markovnikov's rule , epoxide , hydroformylation , organic chemistry , photochemistry , combinatorial chemistry , medicine , alternative medicine , pathology
Welcome to radical catalysis : Radicals are “tamed” in transition‐metal complexes which serve as catalysts for a number of reactions—Kumada couplings (see scheme), highly regioselective cobalt‐catalyzed eliminations, Markovnikov additions, and reductive epoxide openings catalyzed by a titanium/rhodium system. All of these reactions are powered by the high reactivity of radical intermediates in the catalytic cycle of the metal‐catalyzed process.