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The Challenge of Atropisomerism in Drug Discovery
Author(s) -
Clayden Jonathan,
Moran Wesley J.,
Edwards Paul J.,
LaPlante Steven R.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901719
Subject(s) - atropisomer , drug discovery , drug , conformational isomerism , chemistry , computational biology , nanotechnology , stereochemistry , medicine , pharmacology , materials science , biology , organic chemistry , biochemistry , molecule
A twist in the tale : Recent reports have highlighted solutions to the problems encountered when drug candidates exist as slowly interconverting conformers or atropisomers (see scheme). This Minireview brings together the various strategies that have been adopted and proposes a general approach to handling an aspect of stereochemistry which has received little attention from drug regulatory agencies.