Synthetic α‐Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation | Zendy

Saraogi Ishu | Zendy; Hebda James A. | Zendy; Becerril Jorge | Zendy; Estroff Lara A. | Zendy; Miranker Andrew D. | Zendy; Hamilton Andrew D. | Zendy

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Synthetic α‐Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

Author(s) -

Saraogi Ishu,

Hebda James A.,

Becerril Jorge,

Estroff Lara A.,

Miranker Andrew D.,

Hamilton Andrew D.

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200901694

Subject(s) - islet , amyloid (mycology) , chemistry , pharmacology , biochemistry , biophysics , medicine , endocrinology , diabetes mellitus , biology , inorganic chemistry

Split personality : A series of oligoamide‐based helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid‐free conditions, but inhibited it under lipid‐catalyzed conditions. hIAPP=human IAPP.

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