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Synthetic α‐Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation
Author(s) -
Saraogi Ishu,
Hebda James A.,
Becerril Jorge,
Estroff Lara A.,
Miranker Andrew D.,
Hamilton Andrew D.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901694
Subject(s) - islet , amyloid (mycology) , chemistry , helix (gastropod) , biochemistry , peptide , biophysics , biology , endocrinology , diabetes mellitus , inorganic chemistry , ecology , snail
Split personality : A series of oligoamide‐based helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid‐free conditions, but inhibited it under lipid‐catalyzed conditions. hIAPP=human IAPP.