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Controlled Iterative Cross‐Coupling: On the Way to the Automation of Organic Synthesis
Author(s) -
Wang Congyang,
Glorius Frank
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901680
Subject(s) - automation , palladium , coupling (piping) , scheme (mathematics) , computer science , repetition (rhetorical device) , reactivity (psychology) , combinatorial chemistry , modulation (music) , chemistry , nanotechnology , catalysis , materials science , engineering , organic chemistry , mathematics , physics , mechanical engineering , medicine , mathematical analysis , linguistics , philosophy , alternative medicine , pathology , acoustics
Repetition does not hurt! New strategies for the modulation of the reactivity of difunctional building blocks are discussed, allowing the palladium‐catalyzed controlled iterative cross‐coupling and, thus, the efficient formation of complex molecules of defined size and structure (see scheme). As in peptide synthesis, this development will enable the automation of these reactions. M PG =protected metal, M act =metal.