Premium
Three‐Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells
Author(s) -
Wang Shutao,
Wang Hao,
Jiao Jing,
Chen KuanJu,
Owens Gwen E.,
Kamei Kenichiro,
Sun Jing,
Sherman David J.,
Behrenbruch Christian P.,
Wu Hong,
Tseng HsianRong
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901668
Subject(s) - medicine , molecular imaging , library science , computer science , biology , microbiology and biotechnology , in vivo
A grabby substrate : A 3D nanostructured substrate, namely, a silicon‐nanopillar (SiNP) array coated with epithelial‐cell adhesion‐molecule antibody (anti‐EpCAM), shows enhanced local topographic interactions between nanoscale cell‐surface components and the substrates surface, resulting in enhanced cell‐capture efficiency when employed to isolate viable cancer cells from whole‐blood samples (see schematic and SEM image of a captured cancer cell).