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Spiro[4,4]‐1,6‐nonadiene‐Based Phosphine–Oxazoline Ligands for Iridium‐Catalyzed Enantioselective Hydrogenation of Ketimines
Author(s) -
Han Zhaobin,
Wang Zheng,
Zhang Xumu,
Ding Kuiling
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901630
Subject(s) - iridium , enantioselective synthesis , oxazoline , phosphine , asymmetric hydrogenation , catalysis , chemistry , combinatorial chemistry , organic chemistry , medicinal chemistry
From imines to amines through catalysis by Ir I complexes of a new type of P,N ligand (see scheme): This reaction affords the corresponding optically active amines with up to 98 % ee and has also been used with perfect stereoselectivity in the asymmetric synthesis of sertraline ( 1 ), an important antidepressant chiral drug.